ProductDescription
MitomycinCisaquinone-basedantitumorantibioticthatcrosslinksthecomplementarystrandsoftheDNAdoublehelixwithexquisitebase-andregioselectivityfortheN2ofguanine.(1)Itfirstenteredclinicaltrialsin1958hasbeenemployedsince1974incombinationchemotherapytreatments(2)
MitomycinChasbeenshowntoinduceapoptosisthroughcaspaseprocessing.InMCF-7breastcancercelllines,mitomycinCtreatmentledtoactivecaspase-7,-8,and-9processing,withminimaleffecttocaspase-3.(3)
Morerecently,mitomycinCwasobservedtoactirreversIBLyuponthioredoxinreductase(TrxR)inatime-andconcentration-dependentmanner.InDTNBandinsulinassays,mitomycinCinhibitedTrxRatIC50sof3uMand1uM,respectively.(4)
Technicalinformation:
| ChemicalFormula: | | C15H18N4O5 |
| CAS#: | | 50-07-7 |
| MolecularWeight: | | 334.33 |
| Purity: | | >98% |
| Appearance: | | purplesolid |
| ChemicalName: | | [6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2",3":3,4]pyrrolo[1,2-a]indol-8-yl]methylcarbamate |
| Solubility: | | Upto20mMinDMSO |
| Synonyms: | | |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Tomasz,M.,MitomycinC:small,fast,anddeadly(butveryselective).Chem.Biol.1995,2,575-579.PubmedID:9383461 |
| 2. | Crookeetal.,MitomycinC:areview.CancerTreatmentRev.1976,3,121-139.PubmedID:786455 |
| 3. | Pirniaetal.,MitomycinCinducesapoptosisandcaspase-8and-9processingthroughacaspase-3andFas-independentpathway.CellDeathDifferentiation,2002,9,905-914.PubmedID:12181741 |
| 4. | Pazetal.,ANewMechanismofActionfortheAnticancerDrugMitomycinC:Mechanism-BasedInhibitionofThioredoxinReductase.Chem.Res.Toxicol.2012,25,1502-1511.PubmedID:786455 |
品牌介绍
Cellagen Technology 公司位于美国加州San Diego，该公司致力于干细胞相关产品的研发和生产。基于多年为世界*的生物公司提供OEM产品的经验，目前Cellagen Technology公司利用自身优势，拓展了原有产品线，推出了以StemRegenin 1（SR1）为代表的多种自有品牌产品。 NamePriceCat # （Powder）Cat # （10 mM in DMSO）Pathway/Target7,8-Dihydroxyflavone1173C7181-10N/ATrkBA7696622023C2769-10N/AAMPKA83-011513C2831-2C2831-2sTGF-β/ALK4,5,7Abiraterone1853C2247-2C2247-2sP450-CYP17BEZ235833C2392-2C2392-2sPI3K, mTORBIX-012941513C2491-5C2491-5sEpigenetics/G9a HMTCHIR990213553C2447-2C2447-2sGSK3β CP-6905501343C2716-2C2716-2sJAK1,2,3Cyclopamine2193C2925-2C2925-2sHedgehog/SmoDAPT1853C3178-5C3178-5sNotch/γ-secretaseForskolin1853C3677-10N/AAdenylate cyclaseFTY7201173C3897-5C3897-5sS1P receptorsGDC-09411513C4321-5C4321-5sPI3KHh-Ag1.53043C4412-2C4412-2sHedgehog/SmoINCB0184241853C4622-2C4622-2sJAK1/2IWP-31853BackorderBackorderWntKHS1011853C5471-5C5471-5sNeural differentiationLDE2252363C5332-2C5332-2sHedgehog/SmoLDN-1931893723C5361-2C5361-2sBMP/ALK2,3Leukadherin-1#VALUE!C5385-2C5385-2sCD11b, CD18LY2940022193C5929-5C5929-5sPI3KP7C32363C7723-10N/Aneurogenic, neuroprotectivePD03259013723C7303-2C7303-2sMEK1, MEK2PD03329912193C7306-2C7306-2sCdk4, Cdk6PS481343C7748-5C7748-5sPDK1Pyrintegrin3383C7974-1C7974-1sES cell survivalR4062193C7406-2C7406-2sSykR7883723C7788-5C7788-5sSykRapamycin2193C7272-5C7272-5smTORReversine1173C7383-2C7383-2sA3 Adenosine ReceptorRO49290972703C7649-2C7649-2sNotch/γ-secretaseSB4315421513C7243-5C7243-5sTGF-β/ALK4,5,7SF16703723C7316-2C7316-2spTENSitagliptin1513C7482-5C7482-5sDPP-4SRT17202363C7781-2C7781-2sSIRT1StemRegenin1 （SR1）3723C7710-1C7710-1sAryl hydrocarbon receptorSU54022703C7854-1C7854-1sFGFRThiazovivin3553C8442-1C8442-1sROCKUrsolic Acid1853C8776-10N/ASTAT3VX-6801173C8916-10N/AAurora kinaseWnt-C592703C7641-2C7641-2sWntXAV9392703C9289-2C9289-2sWntY-276321853C9127-2C9127-2sROCKhuman Activin A5423P4228-1031910 µg37383P4228-1002199100 µghuman BMP-4 3723P4267-1021910 µg25483P4267-1001499100 µghuman bFGF 3383P4234-5019950 µg23783P4234-5001399500 µgmouse LIF 3383P6543-1019910 µg23783P6543-1001399100 µghuman Wnt-3a 3723P4968-1021910 µg
