Cellagentech/NVP-LGK974 | Wnt抑制剂/C6545-2s/2 mg（10 mM二甲基亚砜溶液）
商品编号：
C6545-2s
品牌：
cellagentech
市场价：
¥3180.00
美元价：
1908.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
ProductDescription
LGK974isapotentandorallyactiveWntpathwayinhibitorwithanIC50<1nMintheWntsignalingassay[1].ItinhibitsacylationofWntproteinsbyPorcupine(Porcn).LGK974specificallyblockstheproliferationofpancreaticcancercellsthathaveup-regulatedWntsignalingcausedbycarryinginactivemutationsinaUbiquitinE3ligase,RNF43[2].
LGK974robustlysuppressedWntsignalinginvivoresultingintumorregressioninamurinebreastcancermodeldrivenbyMMTV-Wnt1,andshowedexcellentefficacyinxenograftmodelsofheadandnecksquamouscellcarcinomaandpancreaticcancer[3].CurrentlyLGK974isinthePhaseIstudytotreatpatientswithdifferenttypesofWntsignaling-drivencancers[4].
Technicalinformation:
| ChemicalFormula: | C23H20N6O | |
| CAS#: | 1243244-14-5 | |
| MolecularWeight: | 396.44 | |
| Purity: | >98% | |
| Appearance: | White | |
| ChemicalName: | 2-(2",3-dimethyl-[2,4"-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide | |
| Solubility: | Upto100mMinDMSO | |
| Synonyms: | NVP-LGK974,LGK974 |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderorDMSOsolutionat-20oCdesiccated.
Reference:
| 1. | ShifengPan.DiscoveryofLGK974:AselectivePorcupineinhibitortargetingWntsignalingincancer.AACRAnnualMeeting2013. |
| 2. | JiangX,etal.InactivatingmutationsofRNF43conferWntdependencyinpancreaticductaladenocarcinoma.ProcNatlAcadSciUSA.2013;110(31):12649-54.PubmedID:23847203 |
| 3. | LiuJ,etal.TargetingWnt-drivencancerthroughtheinhibitionofPorcupinebyLGK974.ProcNatlAcadSciUSA.2013;110(50):20224-9PubmedID:24277854 |
| 4. | http://clinicaltrials.gov/show/NCT01351103 |
品牌介绍
Cellagen Technology 公司位于美国加州San Diego，该公司致力于干细胞相关产品的研发和生产。基于多年为世界*的生物公司提供OEM产品的经验，目前Cellagen Technology公司利用自身优势，拓展了原有产品线，推出了以StemRegenin 1（SR1）为代表的多种自有品牌产品。 NamePriceCat # （Powder）Cat # （10 mM in DMSO）Pathway/Target7,8-Dihydroxyflavone1173C7181-10N/ATrkBA7696622023C2769-10N/AAMPKA83-011513C2831-2C2831-2sTGF-β/ALK4,5,7Abiraterone1853C2247-2C2247-2sP450-CYP17BEZ235833C2392-2C2392-2sPI3K, mTORBIX-012941513C2491-5C2491-5sEpigenetics/G9a HMTCHIR990213553C2447-2C2447-2sGSK3β CP-6905501343C2716-2C2716-2sJAK1,2,3Cyclopamine2193C2925-2C2925-2sHedgehog/SmoDAPT1853C3178-5C3178-5sNotch/γ-secretaseForskolin1853C3677-10N/AAdenylate cyclaseFTY7201173C3897-5C3897-5sS1P receptorsGDC-09411513C4321-5C4321-5sPI3KHh-Ag1.53043C4412-2C4412-2sHedgehog/SmoINCB0184241853C4622-2C4622-2sJAK1/2IWP-31853BackorderBackorderWntKHS1011853C5471-5C5471-5sNeural differentiationLDE2252363C5332-2C5332-2sHedgehog/SmoLDN-1931893723C5361-2C5361-2sBMP/ALK2,3Leukadherin-1#VALUE!C5385-2C5385-2sCD11b, CD18LY2940022193C5929-5C5929-5sPI3KP7C32363C7723-10N/Aneurogenic, neuroprotectivePD03259013723C7303-2C7303-2sMEK1, MEK2PD03329912193C7306-2C7306-2sCdk4, Cdk6PS481343C7748-5C7748-5sPDK1Pyrintegrin3383C7974-1C7974-1sES cell survivalR4062193C7406-2C7406-2sSykR7883723C7788-5C7788-5sSykRapamycin2193C7272-5C7272-5smTORReversine1173C7383-2C7383-2sA3 Adenosine ReceptorRO49290972703C7649-2C7649-2sNotch/γ-secretaseSB4315421513C7243-5C7243-5sTGF-β/ALK4,5,7SF16703723C7316-2C7316-2spTENSitagliptin1513C7482-5C7482-5sDPP-4SRT17202363C7781-2C7781-2sSIRT1StemRegenin1 （SR1）3723C7710-1C7710-1sAryl hydrocarbon receptorSU54022703C7854-1C7854-1sFGFRThiazovivin3553C8442-1C8442-1sROCKUrsolic Acid1853C8776-10N/ASTAT3VX-6801173C8916-10N/AAurora kinaseWnt-C592703C7641-2C7641-2sWntXAV9392703C9289-2C9289-2sWntY-276321853C9127-2C9127-2sROCKhuman Activin A5423P4228-1031910 µg37383P4228-1002199100 µghuman BMP-4 3723P4267-1021910 µg25483P4267-1001499100 µghuman bFGF 3383P4234-5019950 µg23783P4234-5001399500 µgmouse LIF 3383P6543-1019910 µg23783P6543-1001399100 µghuman Wnt-3a 3723P4968-1021910 µg
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