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当前位置: 首页 > 产品中心 > Stimulus > Cellagen/Categories/5mg(10mM二甲基亚砜溶液)/C4001-5
商品详细Cellagen/Categories/5mg(10mM二甲基亚砜溶液)/C4001-5
Cellagen/Categories/5mg(10mM二甲基亚砜溶液)/C4001-5
Cellagen/Categories/5mg(10mM二甲基亚砜溶液)/C4001-5
商品编号: C4001-5
品牌: cellagentech
市场价: ¥2580.00
美元价: 1548.00
产地: 美国(厂家直采)
公司:
产品分类: 刺激/抑制试剂
公司分类: Stimulus
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF-responsive genes. ICG-001 binds specifically to cyclic AMP response element-binding protein (CBP), therby disrupting interaction of CBP with b-catenin. [1] ICG-001 selectively induces apoptosis in transformed, but not normal colon cells, and reduces in vitro growth of colon carcinoma cells.ICG-001 has also been shown to attenuate bleomycin-induced lung fibrosis in mice by selective inhibition of Wnt/b-catenin-dependent transcription. [2] ICG-001 is believed to correct defects in neuronal stem cell differentiation by inhibition of this pathway [3] and associated polytopic protein Presenilin-1 (PS-1), which suggests potential therapies in Alzheimer"s disease.The wnt/b-catenin signalling pathway has been implicated in regulation of cancer stem cells and ICG-001 has been studied in this regard. [4]


Technical information:

Chemical Formula: C33H32N4O4
CAS #: 847591-62-2;780757-88-2
Molecular Weight: 548.63
Purity: > 98%
Appearance: White
Chemical Name: (6S,9aS)-6-(4-hydroxybenzyl)-N-benzyl-8-(naphthalen-1-ylmethyl)-4,7-dioxo-hexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Solubility: Up to 100mM in DMSO
Synonyms: ICG-001, ICG001

Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Emami et al., A small molecule inhibitor of beta-catenin/CREB-binding protein transcription. Proc. Natl. Acad. Sci. 2004, 101(34), 12682-12687. Pubmed ID:15314234
2. Henderson et al., Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc. Natl. Acad. Sci. 2010, 107(32), 14309-14314. Pubmed ID:20660310
3. Teo et al., Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Proc. Natl. Acad. Sci. 2005, 102(34), 12171-12176. Pubmed ID:16093313
4. Takahashi-Yanaga et al., Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clin. Cancer Res. 2010, 16, 3153-3162. Pubmed ID:20660310

Other Information:

Product Specification (pdf) MSDS (pdf) Certificate of Analysis is available upon request.

品牌介绍
Cellagen Technology 公司位于美国加州San Diego,该公司致力于干细胞相关产品的研发和生产。基于多年为世界*的生物公司提供OEM产品的经验,目前Cellagen Technology公司利用自身优势,拓展了原有产品线,推出了以StemRegenin 1(SR1)为代表的多种自有品牌产品。 NamePriceCat # (Powder)Cat # (10 mM in DMSO)Pathway/Target7,8-Dihydroxyflavone1173C7181-10N/ATrkBA7696622023C2769-10N/AAMPKA83-011513C2831-2C2831-2sTGF-β/ALK4,5,7Abiraterone1853C2247-2C2247-2sP450-CYP17BEZ235833C2392-2C2392-2sPI3K, mTORBIX-012941513C2491-5C2491-5sEpigenetics/G9a HMTCHIR990213553C2447-2C2447-2sGSK3β CP-6905501343C2716-2C2716-2sJAK1,2,3Cyclopamine2193C2925-2C2925-2sHedgehog/SmoDAPT1853C3178-5C3178-5sNotch/γ-secretaseForskolin1853C3677-10N/AAdenylate cyclaseFTY7201173C3897-5C3897-5sS1P receptorsGDC-09411513C4321-5C4321-5sPI3KHh-Ag1.53043C4412-2C4412-2sHedgehog/SmoINCB0184241853C4622-2C4622-2sJAK1/2IWP-31853BackorderBackorderWntKHS1011853C5471-5C5471-5sNeural differentiationLDE2252363C5332-2C5332-2sHedgehog/SmoLDN-1931893723C5361-2C5361-2sBMP/ALK2,3Leukadherin-1#VALUE!C5385-2C5385-2sCD11b, CD18LY2940022193C5929-5C5929-5sPI3KP7C32363C7723-10N/Aneurogenic, neuroprotectivePD03259013723C7303-2C7303-2sMEK1, MEK2PD03329912193C7306-2C7306-2sCdk4, Cdk6PS481343C7748-5C7748-5sPDK1Pyrintegrin3383C7974-1C7974-1sES cell survivalR4062193C7406-2C7406-2sSykR7883723C7788-5C7788-5sSykRapamycin2193C7272-5C7272-5smTORReversine1173C7383-2C7383-2sA3 Adenosine ReceptorRO49290972703C7649-2C7649-2sNotch/γ-secretaseSB4315421513C7243-5C7243-5sTGF-β/ALK4,5,7SF16703723C7316-2C7316-2spTENSitagliptin1513C7482-5C7482-5sDPP-4SRT17202363C7781-2C7781-2sSIRT1StemRegenin1 (SR1)3723C7710-1C7710-1sAryl hydrocarbon receptorSU54022703C7854-1C7854-1sFGFRThiazovivin3553C8442-1C8442-1sROCKUrsolic Acid1853C8776-10N/ASTAT3VX-6801173C8916-10N/AAurora kinaseWnt-C592703C7641-2C7641-2sWntXAV9392703C9289-2C9289-2sWntY-276321853C9127-2C9127-2sROCKhuman Activin A5423P4228-1031910 µg37383P4228-1002199100 µghuman BMP-4 3723P4267-1021910 µg25483P4267-1001499100 µghuman bFGF 3383P4234-5019950 µg23783P4234-5001399500 µgmouse LIF 3383P6543-1019910 µg23783P6543-1001399100 µghuman Wnt-3a 3723P4968-1021910 µg